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Function: model

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File: /data/webdata/smst/application/controllers/Smst.php
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File: /data/webdata/smst/application/controllers/Smst.php
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Budhaditya | SMST
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Achievements

Budhaditya Mukherjee

About


Research Statement


We are new group focusing on different aspects of infectious intracellular protozoan pathogens using Leishmania, Toxoplasma and Plasmodium as model system.  My research has always focused on different immunological and cellular aspects of parasite biology, that enables these intracellular pathogens to survive within the hostile host enviornment. My scholarship has rendered around theories and methods of protozoan parasitic diseases with applications to clinical importance. We have contributed significantly in the field of drug resistance leishmaniasis one of the major emerging problem for India with new cases reported every year. For a better understanding of protozoan mediated infectious disease I started working on Plasmodium and Toxoplasma causative agents of Malaria & Toxoplasmosis as an EMBO-Post-doctoral fellow. My post-doctoral scholarship primarily articulate in successfully characterized key factors involved in establishing successful infection and dissemination of apicomplexan parasites into or out of the host. During this peroid I also  managed a collaborative project with industrial partner UCB Pharma S.A and Medicines for Malaria Venture (MMV) to design biochemical assays for therapeutic development.
My research interest is interdisciplinary in nature, and our lab want to explore the possibility to establish a potent CRISPR-Cas9 based genome editing techniques in protozoan biology, which in turn could be implemented in characterization of key components of disease pathogenesis & intra/inter species-transmission of these intracellular pathogens. Another focus of the lab would be to develop biochemical assays for activity-based protein profiling to study parasite biology with a particular view of developing them with potential translational value for pharma industries. This should also serve as the base to challenge the existing problem of drug resistance and absence of vaccine, and help in designing of novel drug targets against these pathogens which currently is affecting a huge part of population each year.

Research

  • 1 Infectious protozoan pathogens
  • 2 Immunobiology & Cell biology
  • 3 Host-Parasite interaction
  • 4 Cell Signaling
  • 5 Biochemical assay development

Publications

  • 1. Pradhan S, Snehlata, Manna D, Karmakar S, Singh MK, Bhattacharya A, Mukherjee B, Paul J, Activation of TLR-pathway to induce host Th1 immune response against visceral leishmaniasis: Involvement of galactosylated-flavonoids, Heliyon, 2022
  • Ghosh S, Biswas S, Mukherjee S, Pal A, Saxena A, Sundar S, Dujardin JC, Das S, Roy S, Mukhopadhyay R, Mukherjee B, A novel bioimpedance based detection of Miltefosine susceptibility among clinical Leishmania donovani isolates of the Indian subcontinent exhibiting resistance to multiple drugs, Front Cell Infect Microbiol, 2021
  • Sharma N, Kashif M, Vigyasa Singh, Fontinha D, Mukherjee B, Kumar D, Singh S, Prudencio M, Agam P Singh AP, Rathi B, Novel Antiplasmodial Compounds Leveraged with Multistage Potency against the Parasite Plasmodium falciparum: In Vitro and In Vivo Evaluations and Pharmacokinetic Studies, J Med Chem, 2021
  • Gaëlle Lentini G, Ben Chaabene R, Vadas O, Ramakrishnan C, Mukherjee B, Mehta V, Lunghi M, Grossmann J, Maco B, Visentin R, Hehl AB, Korkhov VM, Soldati-Favre D, Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion, Nature Communication, 2021
  • Mukherjee S, Pradhan S, Ghosh S, Sundar S, Das S, Mukherjee B, Roy S, Short-Course Treatment with Imipramine Entrapped in Squalene Liposomes Results in Sterile Cure of Experimental Visceral Leishmaniasis Induced by Antimony Resistant Leishmania donovani With Increased Efficacy, Front Cell Infect Microbiol, 2020
  • Mukherjee B*, Mukherjee K, Nanda P, Mukhopadhayay R, Ravichandiran V, Bhattacharyya SN, Roy S, Probing the molecular mechanism of aggressive infection by antimony resistant Leishmania donovani, Cytokine, 2020
  • Mukherjee B., Tessaro F. , Vahokoski J. , Kursula I. , Marq J. , Scapozza L. , Soldati-favre D., Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases, EMBO J, 98047-98062, 2018
  • Dogga S. K., Mukherjee B. , Jacot D. , Malino L. , Hammoudi P. , Hartkoorn R. , Hell A. , Soldat-favre D, A drugable secretory protein maturase of Toxoplasma essential for invasion and egress, Elife, 2017
  • Pino P., Caldelari R. , Mukherjee B. , Vahokoski J. , Klages N. , Maco B. , Collins C. ., Blackman M. J., Kursula I. , Heussler V. , Brochet M. , Soldati-favre D., A multi-stage antimalarial targets the plasmepsins IX and X essential for invasion and egress, Science, 358, 522-528, 2017
  • Mukherjee B., Paul J. , Mukherjee S. , Mukhopadhyay R. , Das S. , Naskar K. , Dujardin J. , Roy S., Antimony-Resistant Leishmania donovani Exploits miR-466i To Deactivate Host MyD88 for Regulating IL-10/IL-12 Levels during Early Hours of Infection, J. Immunol, 195, 2731-2742, 2015
  • Mukherjee S., Mukherjee B. , Mukhopadhyay R. , Naskar K. , Dujardin J. , Roy S, Imipramine exploits Histone deacetylase 11 to increase IL-12/IL-10 ratio in macrophages infected with antimony resistant Leishmania donovani and clears organ parasite in experimental infection, J. Immunol, 193, 4083-4094, 2014
  • Mukherjee B., Mukhopadhyay R. , Bannerjee B. , Chowdhury S. , Naskar K. , Allam U. , Chakravortty D. , Sundar S. , Dujardin J. , Roy S., Antimony resistant Leishmania donovani upregulates IL-10 to overexpress host multi drug resistant protein1, Proc Natl Acad Sci U S A, 110, 575-582, 2013
  • Chowdhury S., Mukherjee T. , Mukhopadhyay R. , Mukherjee B. , Sengupta S. , Chattopadhyay S. , Jaisankar P. , Roy S. , Majumder H., The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice, EMBO Mol Med, 1126-1143 (, 2012
  • Mukhopadhyay R., Mukherjee S. , Mukherjee B. , Naskar K. , Mondal D. , Decuypere S. , Ostyn B. , Prajapati V. , Sundar S. , Dujardin J. , Roy S., Characterisation of antimony-resistant Leishmania donovani isolates: biochemical and biophysical studies and interaction with host cells, Int J Parasitol, 1311-1321, 2011
  • Pradhan S, Ghosh S, Hussain S, Paul J, Mukherjee B, Linking membrane fluidity with defective antigen presentation in leishmaniasis. Parasite Immunol, Parasite Immunol

Projects

  • Mechanistic investigation of the complex inter-relationship between HbE/Betathalassemia and protozoan parasite infections with HLA association
  • Community-Based Intervention to Address Antibiotic Resistance: An Embedded Mixed-Methods Interventional Study
  • Unravelling differential metabolic regulation in drug-resistant and sensitive clinical Leishmania donovani (LD) isolates as a possible cause of altered immune metabolic phenotype in the infected host
  • Comparative assessment of the neutralization efficacy of Indigenous vaccines against prevailing variants of concerns of SARS-CoV-2 circulating in India
  • CRISPR-Cas based rapid diagnostics of Miltefosine susceptible and resistant strains of Leishmania donovani from asymptomatic and post kala azar dermal leishmaniasis using invasive and non-invasive approach
  • Molecular & biochemical characterization of amastigote specific proteases involved in late-stage infection & dissemination of drug resistant & sensitive clinical Leishmania donovani isolates
  • Production of SARS-COV-2 c-DNA library with specific genome architecture of Indian Isolates for subsequent development of centralized In-House Repository of Recombinant Antigen and Antibody
  • Identification and Characterization of Proteins Involved in Transmission Machinery of Protozoan Pathogens

Awards

  • Indian Young National Science Academy (INYAS)
  • Pfizer Research Award in the area of infectious diseases, rheumatology and immunology
  • INSA Medal for Young Scientist
  • Swiss Government Excellence Scholarship
  • EMBO long term European Fellowship
  • ParaFrap International Fellowship
  • CSIR, India, National Eligibility Test (NET) PhD Fellowship

Research Group

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Debolina Manna
Ph.D
Research Scholars
Host Parasite Interaction
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Shatarupa Bhattacharya
Ph.D
Research Scholars
Toxoplasma infection in Thalassemia
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Shubhangi Chakraborty
Ph.D
Tropism in parasitic infection
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Souradeepa Ghosh
Ph.D
Research Scholars
Infectious disease and immunology, Leishmania
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Supratim Pradhan
Ph.D
Research Scholars
Infectious disease and immunology, Leishmania