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Message: Creation of dynamic property CI_URI::$config is deprecated

Filename: core/URI.php

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Backtrace:

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property CI_Router::$uri is deprecated

Filename: core/Router.php

Line Number: 127

Backtrace:

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

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Filename: core/Controller.php

Line Number: 75

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

Message: Creation of dynamic property Smst::$benchmark is deprecated

Filename: core/Controller.php

Line Number: 75

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

Message: Creation of dynamic property Smst::$hooks is deprecated

Filename: core/Controller.php

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Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

Message: Creation of dynamic property Smst::$config is deprecated

Filename: core/Controller.php

Line Number: 75

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

Message: Creation of dynamic property Smst::$utf8 is deprecated

Filename: core/Controller.php

Line Number: 75

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

Message: Creation of dynamic property Smst::$uri is deprecated

Filename: core/Controller.php

Line Number: 75

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

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Filename: core/Controller.php

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Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

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Filename: core/Controller.php

Line Number: 75

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

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Filename: core/Controller.php

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Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

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Filename: core/Controller.php

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File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

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Filename: core/Controller.php

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File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

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Filename: core/Controller.php

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Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

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Filename: core/Controller.php

Line Number: 78

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

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Filename: core/Loader.php

Line Number: 396

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

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Filename: database/DB_driver.php

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Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

Message: Creation of dynamic property Smst::$email is deprecated

Filename: core/Loader.php

Line Number: 1283

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

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Filename: drivers/Session_files_driver.php

Line Number: 132

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

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Line Number: 292

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

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Filename: drivers/Session_files_driver.php

Line Number: 166

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

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Filename: drivers/Session_files_driver.php

Line Number: 235

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

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Filename: drivers/Session_files_driver.php

Line Number: 315

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

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Filename: drivers/Session_files_driver.php

Line Number: 356

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: Warning

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Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: Warning

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Filename: Session/Session.php

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Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: Warning

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Line Number: 304

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: Warning

Message: ini_set(): Session ini settings cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 314

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: Warning

Message: ini_set(): Session ini settings cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 315

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: Warning

Message: ini_set(): Session ini settings cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 316

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: Warning

Message: ini_set(): Session ini settings cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 317

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: Warning

Message: ini_set(): Session ini settings cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 375

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: Warning

Message: session_set_save_handler(): Session save handler cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 110

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: Warning

Message: session_start(): Session cannot be started after headers have already been sent

Filename: Session/Session.php

Line Number: 143

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

Message: Creation of dynamic property Smst::$session is deprecated

Filename: core/Loader.php

Line Number: 1283

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 14
Function: __construct

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property Smst::$User is deprecated

Filename: core/Loader.php

Line Number: 358

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 15
Function: model

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property Smst::$Content is deprecated

Filename: core/Loader.php

Line Number: 358

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 16
Function: model

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property Smst::$image_lib is deprecated

Filename: core/Loader.php

Line Number: 1283

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 20
Function: library

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property CI_Loader::$log is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

File: /data/webdata/smst/application/controllers/Smst.php
Line: 659
Function: Header

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property CI_Loader::$benchmark is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

File: /data/webdata/smst/application/controllers/Smst.php
Line: 659
Function: Header

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property CI_Loader::$hooks is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

File: /data/webdata/smst/application/controllers/Smst.php
Line: 659
Function: Header

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property CI_Loader::$config is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

File: /data/webdata/smst/application/controllers/Smst.php
Line: 659
Function: Header

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property CI_Loader::$utf8 is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

File: /data/webdata/smst/application/controllers/Smst.php
Line: 659
Function: Header

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property CI_Loader::$uri is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

File: /data/webdata/smst/application/controllers/Smst.php
Line: 659
Function: Header

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property CI_Loader::$exceptions is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

File: /data/webdata/smst/application/controllers/Smst.php
Line: 659
Function: Header

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property CI_Loader::$router is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

File: /data/webdata/smst/application/controllers/Smst.php
Line: 659
Function: Header

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property CI_Loader::$output is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

File: /data/webdata/smst/application/controllers/Smst.php
Line: 659
Function: Header

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property CI_Loader::$security is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

File: /data/webdata/smst/application/controllers/Smst.php
Line: 659
Function: Header

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property CI_Loader::$input is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

File: /data/webdata/smst/application/controllers/Smst.php
Line: 659
Function: Header

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

Message: Creation of dynamic property CI_Loader::$lang is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

File: /data/webdata/smst/application/controllers/Smst.php
Line: 659
Function: Header

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

Message: Creation of dynamic property CI_Loader::$load is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

File: /data/webdata/smst/application/controllers/Smst.php
Line: 659
Function: Header

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

Message: Creation of dynamic property CI_Loader::$db is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

File: /data/webdata/smst/application/controllers/Smst.php
Line: 659
Function: Header

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

Message: Creation of dynamic property CI_Loader::$email is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

File: /data/webdata/smst/application/controllers/Smst.php
Line: 659
Function: Header

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

Message: Creation of dynamic property CI_Loader::$session is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

File: /data/webdata/smst/application/controllers/Smst.php
Line: 659
Function: Header

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

Message: Creation of dynamic property CI_Loader::$User is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

File: /data/webdata/smst/application/controllers/Smst.php
Line: 659
Function: Header

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

Message: Creation of dynamic property CI_Loader::$Content is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

File: /data/webdata/smst/application/controllers/Smst.php
Line: 659
Function: Header

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

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Severity: 8192

Message: Creation of dynamic property CI_Loader::$image_lib is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

File: /data/webdata/smst/application/controllers/Smst.php
Line: 659
Function: Header

File: /data/webdata/smst/index.php
Line: 315
Function: require_once

Gayatri | SMST
Pre-loader

Gayatri Mukherjee

About


Research Statement


Ours is an Immunology laboratory that is interested in teasing out the intricacies of immune response and immune tolerance. To that end, we are interested in deciphering the molecular pathways that help maintain the balance between immune response and immune tolerance and utilize that knowledge to better understand autoimmune disease pathogenesis and cancer development.
Immunotherapy is the technique of utilizing one’s own immune system to treat various diseases by inducing, enhancing or suppressing an immune response. The final goal of immunotherapy is to be able to manipulate pertinent immune system components without disturbing the rest. Manipulation of a cellular compartment such as T cells in its entirety or systemic manipulation of immunogical pathways such as costimulatory molecules leads to deleterious side effects like rendering the individual immunocompromised. Therefore, targeted immunotherapeutic strategies which deal with specific cell populations instead of such big-hammer approaches, should be the way forward for the field. Conforming to that idea, we are working to develop T cell-based novel immunotherapeutic strategies in cancer and autoimmunity with the ultimate goal of the development of personalized medicine.

Research

  • 1 Immunology
  • 2 Development of Immunetherapeutics
  • 3 Commensal Microbiota in Cance
  • 4 Immune modulation in atherosclerosis

Publications

  • Chakrabarti R., Kapse B. , Mukherjee G, Soluble immune checkpoint molecules: Serum markers for cancer diagnosis and prognosis, Cancer reports, 2019
  • Katakowski JA, Mukherjee G, Wilner SE, Maier K, Harrison MT, DiLorenzo TP, Levy M, and Palliser D, Delivery of siRNAs to dendritic cells using DEC205-targeted lipid nanoparticles to inhibit immune responses, Mol. Ther, 2016
  • Babad J, Mukherjee G, Follenzi A, Ali R, Shultz L, Santamaria P, Yang O, Roep B, Goldstein H, Greiner D, DiLorenzo TP, Generation of ? cell-specific human T cells by lentiviral transduction and their survival in immunodeficient HLA-transgenic mice, Clin. Exp. Immunol, 179, 2015
  • Chaparro RJ, Schloss C, Smith C, Bando CD, Glucagon-reactive islet infiltrating CD8 T cells in NOD mice, Immunology, 144, 2015
  • Mukherjee G, Geliebter A, Babad J, Santamaria P, Serreze DV, Freeman GJ, Tarbell KV, Sharpe A, Dilorenzo TP, DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8+ T cells independently of PD-1 and PD-L1, Int. Immunol, 2015
  • Prakash RK, Samanta D, McPhee CG, Kay TWH, Almo SC, DiLorenzo TP, Serreze DV, Compensatory mechanisms allow undersized anchor-deficient Class I MHC ligands to mediate pathogenic autoreactive T-cell responses, J Immunol, 193, 2014
  • Antal Z, Baker JC, Smith C, Jarchum I, Babad J, Mukherjee G, Yang Y, Sidney J, Sette A, Santamaria P, DiLorenzo TP., HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8+ T cell epitopes., J Immunol, 188, 2012
  • Chakraborty DC, Mukherjee G, Banerjee P, Banerjee KK, Biswas T., Hemolysin induces Toll-like receptor (TLR)-independent apoptosis and multiple TLR-associated parallel activation of macrophages, J. Biol. Chem, 286, 2011
  • Samanta D*, Mukherjee G*, Ramagopal UA, Chaparro RJ, Nathenson SG, DiLorenzo TP, Almo SC, Structural and functional characterization of a single-chain peptide-MHC molecule that modulates both naive and activated CD8+ T cells, Proc. Natl. Acad. Sci. U S A, 108, 2011
  • Mukherjee G, Dilorenzo TP, The immunotherapeutic potential of dendritic cells in type 1 diabetes., Clin. Exp. Immunol, 161, 2010

Projects

  • BTNL2, a Novel T Cell Coinhibitory Molecule, as a Therapeutic Target in Ulcerative Colitis
  • Development of Antigen specific Cell-free and Cell-based Novel Immunotherapeutic Strategies in Cancer
  • MHC Haplotypes in HBE/Beta Thalassemia: Correlating Disease Heterogeneity and Blood Transfusion Requirements in West Bengal
  • Development of Cell-free Peptide-MHC Based Immunotherapeutic Reagent to Manipulate Cytotoxic T Cells in Cancer

Awards

  • AAI Trainee Abstract Award at IMMUNOLOGY, Annual Meeting of The American Association of Immunologists. Pittsburgh, PA, USA
  • Best Poster award at Dennis Shields Post-Doctoral Award Symposium, Albert Einstein College of Medicine
  • UGC-Senior Research Fellowship
  • UGC-Junior Research Fellowship
  • Qualified the Graduate Aptitude Test Examination conducted by the Indian Institute of Technology
  • Qualified the Joint University Grant Commission (UGC)–Council for Scientific and Industrial Research (CSIR), National Eligibility Test
  • Best presentation award in a seminar series during M.S., Presidency College, Kolkata

Research Group

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Anita Hansda
Ph.D
Research Scholars
Immunology
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Debangshu Mukherjee
Ph.D
Research Scholars
Immunology
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Debarati Biswas
Research Scholars
Immunology
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Dhrubajyoti Mahata
Ph.D
Research Scholars
Immunology
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Krishna Dixit
Ph.D
Research Scholars
Tissue Enginnering
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Rituparna Chakrabarti
Ph.D
Research Scholars
Immune system involvement in cardiac and vascular remodeling
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Sanjukta Dasgupta
Ph.D
Research Scholars
Respiratory health