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Function: __construct

File: /data/webdata/smst/index.php
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Function: __construct

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Function: __construct

File: /data/webdata/smst/index.php
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File: /data/webdata/smst/index.php
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Severity: 8192

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Function: __construct

File: /data/webdata/smst/index.php
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File: /data/webdata/smst/index.php
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File: /data/webdata/smst/index.php
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Severity: 8192

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Function: __construct

File: /data/webdata/smst/index.php
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Function: require_once

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Function: __construct

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Function: __construct

File: /data/webdata/smst/index.php
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Function: __construct

File: /data/webdata/smst/index.php
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Function: __construct

File: /data/webdata/smst/index.php
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File: /data/webdata/smst/index.php
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Function: __construct

File: /data/webdata/smst/index.php
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Function: __construct

File: /data/webdata/smst/index.php
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Function: __construct

File: /data/webdata/smst/index.php
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Function: __construct

File: /data/webdata/smst/index.php
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File: /data/webdata/smst/application/controllers/Smst.php
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File: /data/webdata/smst/index.php
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File: /data/webdata/smst/application/controllers/Smst.php
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Function: model

File: /data/webdata/smst/index.php
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Function: model

File: /data/webdata/smst/index.php
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Line: 96
Function: view

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Function: Header

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File: /data/webdata/smst/application/controllers/Smst.php
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Function: Header

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File: /data/webdata/smst/application/controllers/Smst.php
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Function: view

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File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

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Function: Header

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File: /data/webdata/smst/application/controllers/Smst.php
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Function: view

File: /data/webdata/smst/application/controllers/Smst.php
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Function: Header

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Line Number: 931

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File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

File: /data/webdata/smst/application/controllers/Smst.php
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Function: Header

File: /data/webdata/smst/index.php
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Severity: 8192

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Line Number: 931

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File: /data/webdata/smst/application/controllers/Smst.php
Line: 96
Function: view

File: /data/webdata/smst/application/controllers/Smst.php
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Function: Header

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Function: Header

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Koel | SMST
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Achievements

Koel Chaudhury

About


Research Statement


The Clinical Biomarkers Discovery Laboratory is actively involved in using the newly emerged field of metabolomics, which is capable of providing biological end-point markers of the cellular processes that occur as a result of the disease. Metabolomics has rapidly evolved during recent years and is complementary to different? omics? technologies, such as transcriptomics and proteomics. We focus on the use of metabolomics for comprehensive identification of disease biomarkers and understanding of the pathogenic mechanism underlying complex human diseases. We have extensively used the metabolomics approach to investigate Women?s health with an emphasis on pregnancy-related complications. Early-stage biomarkers specific to Stage I and Stage II endometriosis have been successfully identified and validated. The design of a biochemical sensor based on these findings is underway. Biomarkers for gestational hypertension, recurrent miscarriage, polycystic ovarian syndrome (PCOS), and female dormant genital tuberculosis are also being explored. Recently, our team has initiated work in the area of Respiratory health. We are using metabolomics for the identification of unique metabolic fingerprints in exhaled breath condensates and serum for differentiating the various endotypes/sub-types of asthma and chronic obstructive pulmonary disease (COPD). Dysregulated glucose and lipid metabolism intermediates and amino acid changes between the sub-types have been identified. We are also profiling other respiratory disorders including interstitial lung disease (ILD), pulmonary hypertension, and lung cancer with an aim to enhance the scope for novel point of care device development. 

Research

  • 1 Non-invasive biomarkers and sensors
  • 2 Metabolomics
  • 3 Nanomedicine
  • 4 Women's health
  • 5 Respiratory disorders

Publications

  • Bhargava A., Shukla A. , Bunkar N. , Shandilya R. , Lodhi L. , Kumari R. , Gupta P. K., Rahman A. , Chaudhury K. , Tiwari R. , Goryacheva I. Y., Mishra P. K., Exposure to ultrafine particulate matter induces NF- mediated epigenetic modifications, Environmental Pollution, 252, 39-50, 2019
  • Shukla ., Bunkar N. , Kumar R. , Bhargava A. , Tiwari R. , Chaudhury K. , Goryacheva I. , Mishra P., Air pollution associated epigenetic modifications: Transgenerational inheritance and underlying molecular mechanisms, Science of the total environment, 656, 760-777, 2019
  • Ghosh S., Raju R. , Ghosh N. , Chaudhury K. , Ghosh S. , Banerjee . , Pramanik, Development and physicochemical characterization of doxorubicin-encapsulated hydroxyapatite polyvinyl alcohol nanocomposite for repair of osteosarcoma-affected bone tissues, Comptes rendus chimie, 22, 46-57, 2019
  • Singh B., Ghosh N. , Saha D. , Sarkar S. , Bhattacharyya P. , Chaudhury K., Effect of doxycyline in chronic obstructive pulmonary disease-An exploratory study, Pulmonary pharmacology & therapeutics, 2019
  • Chaudhury K., Choudhury P. , Ghosh N. , Joshi M. , Bhattacharyya P, NMR serum metabolomics for understanding the pathophysiology of COPD associated PH: A pilot study, European Respiratory Society Congress, 2018
  • Chaudhury K., Roychoudhury S. , Joshi M. , Chakravarty B., Serum metabolic signatures differentiate women with repeated embryo implantation failure from recurrent implantation success, International Conference of the Metabolomics Society, 2018
  • Dutta M., Singh B. , Joshi M. , Das D. , Subramani E. , Maan M. , Jana S. K., Sharma U. , Das S. , Dasgupta S. , Ray C. D., Chakravarty B. , Chaudhury K, Metabolomics reveals perturbations in endometrium and serum of minimal and mild endometriosis, Scientific Reports, 8, 1-19, 2018
  • Rameshbabu A., Datta S. , Bankoti K. , Subramani E. , Chaudhury K. , Lalzawmliana V. , Nandi S. , Dhara S., Polycaprolactone nanofibers functionalized with placental derived extracellular matrix for stimulating wound healing activity, Journal of materials chemistry B, 6767-6780, 2018
  • Singh R., Shandilya R. , Bhargava A. , Kumar R. , Tiwari R. , Chaudhury K. , Srivastava R. , Goryacheva I. , Mishra P., Quantum dot based nano-biosensors for detection of circulating cell free miRNAs in lung carcinogenesis: from biology to clinical translation, Frontiers in genetics, 2018
  • Siddiqa A. J., Maji S. , Chaudhury K. , Adhikari B., A facile route to develop hydrophilicity on the polyolefin surface for biomedical applications, Advances in Polymer Technology, 37, 1410-1419, 2018
  • Bunkar N., Bhargava A. , Chaudhury K. , Sharma R. S., Lohiya N. K., Mishra P. K., Fetal nucleic acids in maternal plasma: from biology to clinical translation, Frontiers in bioscience, 23, 397-431, 2018
  • Singh B., Jana S. K., Ghosh N. , Das S. K., Joshi M. , Bhattacharyya P. , Chaudhury K., Metabolomic profiling of doxycycline treatment in chronic obstructive pulmonary disease, Journal of Pharmaceutical and Biomedical Analysis, 132, 103-108, 2017
  • T. H., Bagadi M. , Roychoudhury S. , Dutta M. , Uppal A. , Mane A. , Santra M. K., Chaudhury K. , Rapole S., Comprehensive quantitative lipidomic approach to investigate serum phospholipid alterations in breast cancer, Metabolomics, 2017
  • Ray S., Dutta M. , Chaudhury K. , De B., GC MS based metabolite profiling and angiotensin I-converting enzyme inhibitory property of black tea extracts, RevistaBrasileira de Farmacognosia, 27, 580-586, 2017
  • A., Dabhi R. , Taunk K. , Jagadeeshaprasad M. G., Roychoudhury S. , Mane A. , Bayatigeri S. , Chaudhury K. , Santra M. K., Rapole S., Multipronged quantitative proteomics reveals serum proteome alterations in breast cancer intrinsic subtypes, Journal of Proteomics, 163, 1-13, 2017
  • Point of Care Application by Kare S. P., Das D. , Chaudhury K. , Das S., Fabrication of Cost-effective and Lithographically Patterned Flexible Paper-based Microfluidic Device using Photo-PDMS for Point of Care Application, 26th Anniversary World Congress on Biosensors, 2016
  • Roychoudhury S., Mishra B. P., Khan T. , Chattopadhayay R. , Lodh I. , Ray C. D., Bose G. , Sarkar H. S., Srivastava S. , Joshi M. V., Chakravarty B. , Chaudhury K., Serum metabolomics of Indian women with polycystic ovary syndrome using 1H NMR coupled with a pattern recognition approach, Mol Biosyst, 12, 3407-3416, 2016
  • GHOSH N, DUTTA M, SINGH B, BANERJEE R, BHATTACHARYYA P, CHAUDHURY K, Transcriptomics, proteomics and metabolomics driven biomarker discovery in COPD: an update, Expert Rev Mol Diagn, 16, 897-913, 2016
  • SUBRAMANI E, DUTTA M, JOTHIRAMAJAYAM M,JOSHI M, SRIVASTAVA S, MUKHERJEE A, CHAKRAVARTY BN, CHAUDHURY K., Identification of serum metabolic markers for diagnosis of women with dormant genital tuberculosis, Metabolomics, 2016
  • ROYCHOUDHURY S, SINGH A, GUPTA NJ, SRIVASTAVA S, JOSHI MV, CHAKRAVARTY B, CHAUDHURY K, Repeated implantation failure versus repeated implantation success: discrimination at a metabolomic level, Hum Reprod, 1265-1274, 2016
  • DUTTA, M., SUBRAMANI, E., TAUNK, K., GAJBHIYE, A., SEAL, S., PENDHARKAR, N., DHALI, S., RAY, C. D., LODH, I., CHAKRAVARTY, B., DASGUPTA, S., RAPOLE, S.,CHAUDHURY, K, Investigation of serum proteome alterations in human endometriosis, J Proteomics, 114, 182-196, 2015
  • Ghosh S., Pandey N. K., Banerjee P. , Chaudhury K. , Nagy N. V., Dasgupta S, Copper(II) directs formation of toxic amorphous aggregates resulting in inhibition of hen egg white lysozyme fibrillation under alkaline salt mediated conditions, J. Biomol. Struct. Dyn., 1-17, 2014
  • BANERJEE, P., DUTTA, M., SRIVASTAVA, S., JOSHI, M., CHAKRAVARTY, B. &CHAUDHURY, K, H NMR serum metabonomics for understanding metabolic dysregulation in women with idiopathic recurrent spontaneous miscarriage during implantation window, J Proteome Res, 13, 2014
  • SINGH, A. K., CHATTOPADHYAY, R., CHAKRAVARTY, B. & CHAUDHURY, K., Markers of oxidative stress in follicular fluid of women with endometriosis and tubal infertility undergoing IVF, Reprod. Toxicol, 116-124, 2013
  • DUTTA, M., JOSHI, M., SRIVASTAVA, S., LODH, I., CHAKRAVARTY, B. & CHAUDHURY, K., A metabonomics approach as a means for identification of potential biomarkers for early diagnosis of endometriosis, Mol. Biosyst, 2012
  • Bhattacharya N. S., Manchikanti P. , Chaudhury K., Manufacturing of biodrugs, BioDrugs, 217-229, 2009

Projects

  • A Carbon Nanotube-based Miniaturized Sensor for Differential Diagnosis of Aco form Asthma and COPD
  • National Centre for Technology in Family Welfare (NCTFW)
  • Aberrant Circulation Epigenomic Signatures: Development and Validation of Non-invasive Biomarkers for Trans-generational Monitoring of Air Pollution Associated Cancers
  • Design Food Formulation with Resistant Starch and Protein for Diabetic/nephro-diabetic Patients: An Approach Towards Commercialization

Awards

  • Labhsetwar award
  • Technology Innovation

Patents

  • Biodegradable polymer encapsulated Besifloxacin nanoparticles

Research Group

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Anindita Bhattacharya
Ph.D
Research Scholars
Lung cancer pathogenesis
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Apoorva Singh
Ph.D
Research Scholars
Systems Biology
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Arijit Pal
Ph.D
Research Scholars
Biomedical Sensor development
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Atul Kumar Ojha
Ph.D
Research Scholars
Nanotechnology based biomedical application
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Brajesh Singh
Ph.D
Research Scholars
Respiratory disorder: pathogenesis and therapeutics
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Da Doma Sherpa
Ph.D
Research Scholars
Reproductive health
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Nilanjana Ghosh
Ph.D
Research Scholars
understanding COPD pathogenesis
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Pritha Biswas
Ph.D
Research Scholars
Immunology
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R. Siva Kumar Raju
Ph.D
Research Scholars
Cancer Diagnostic
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Riddhipratim Mandal
Ph.D
Research Scholars
Biosensors
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Sanjukta Dasgupta
Ph.D
Research Scholars
Respiratory health